Development of new isotopes for theranostic applications
The theranostic concept where similar or identical radiopharmaceuticals are used for tandem imaging and therapeutic strategies has been paradigm shifting for the field of nuclear medicine. The theranostic isotope pairing in FDA approved radiopharmaceuticals typically consists of two different radionuclides, for example 68Ga for imaging and 177Lu for therapy. A disadvantage of using this pair is that 68Ga and 177Lu are chemically different, which may result in different pharmacokinetics of radiopharmaceuticals labelled with these two compounds. The ideal theranostic pair would include radioisotopes of the same element (isotope pairs) but with different emissions (i.e., one suitable for diagnosis and the other for therapy). To this end, our group has focused on the production of 43Sc and 47Sc as a true matched theranostic pair for imaging and therapy as well as methods for production of 203Pb as an imaging analogue for the therapeutic isotope 212Pb. More recent work has focused on imaging analogues of F-block radionuclides including 155Tb and 140Nd, Additional research has developed chemistry to incorporate these radioisotopes into new imaging radiopharmaceuticals for preclinical and eventually clinical imaging studies.
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Advanced Studies Gateway Concert by Young Hyun Cho
Program Piano Sonata No. 16 in G major, Op. 31, No. 1 Ludwig van Beethoven (1770-1827) I. Allegro vivace II.Adagio grazioso III. Rondo: Allegretto Piano Sonata No. 17 in D minor, Op. 31, No. 2, "Tempest" Ludwig van Beethoven I. Largo Allegro II.Adagio III.Allegretto Piano Sonata No. 18 in E-flat major, Op. 31, No. 3, "The Hunt" Ludwig van Beethoven Allegro I.Scherzo: Allegretto vivace II.Menuetto: Moderato e grazioso III.Presto con fuoco
